Content: Genomic Epidemiology
Date: September 2021 (exact date will be announced in August). Please email us to register your interest
Duration: (live and pre-recorded session): 7 hours (morning session: 9am to 12pm, afternoon session: 1pm to 4pm)
Structure: Pre-recorded material and a live session. Participants will use the links below to access the pre-recorded content which will be viewed within an allocated time. Participants will then regroup to discuss the course content in a breakout room.
Brief description: The pre-recorded lectures will discuss key topics in genetic association studies, imputation, replication, meta-analysis and causal inference. Participants will be required to familiarise themselves with the pre-recorded content and regroup to discuss the content of the pre-recorded course materials in the live session.
Who should attend: Individuals interested, involved in (or planning) genetic association studies, genotype imputation, polygenic risk scoring and Mendelian randomisation studies.
Objective(s): Introduce key concepts in the design of the statistical association between the genetic variant and disease; the idea of genotype imputation for genome-wide association studies (GWAS); how genetic associations are confirmed in further studies with the concept of combining multiple GWAS into a single summary result; how we can use polygenic risk scores to stratify individuals according to their risk of disease; and the idea of using variation in genes to examine the causal effect of a modifiable exposure on disease.
Learning outcomes: Participants will be able to describe different concepts in genomic epidemiology including genetic association studies, polygenic risk scoring and Mendelian randomisation studies.